Formic Acid Reduction. VI. Barbituric Acid Derivatives. Reduction of 5-Arylaminomethylene- and 5-Alkylaminomethylene-substituted Barbituric Acids converting to 5-Methylbarbituric Acids
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منابع مشابه
The nonenzymatic decomposition of 5-methylbarbituric acid.
Studies with Mycobacterium and Corynebacterium, which metabolize pyrimidines via the oxidative pathway (l-5), have revealed that the first product of thymine catabolism is 5-methylbarbituric acid. The metabolic fate of 5-methylbarbituric acid remains to be elucidated. Work in this laboratory has shown that 5-methylbarbituric acid supports growth of Corynebacterium and is rapidly metabolized by ...
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Since the 1864 landmark discovery by Adolf von Baeyer, barbituric acids have played a prominent role in medicine and organic synthesis. The barbituric acid scaffold occurs in more than 5000 pharmacologically active compounds, including commonly used anticonvulsant, hypnotic, and anticancer agents (Figure 1a). Moreover, as an easily accessible feedstock material, it is an extremely useful buildi...
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or luminal (di-phenyl-barbiturie acid), (7) sodium luminal, (8) phanodorn (cyclo-hexenyl-ethyl-barbituric acid), (9) evipan (N. methyl-cyclo-hexenyl-methylbarbituric acid), (10) sodium evipan, (11) pentobarbitone (ethyl-methyl-butyl-barbituric acid) and (12) its sodium salt, nembutal, (13) ipral (calcium ethyl iso-propyl-barbituric acid), (14) allonal (a combination of allyl-iso-propyl-barbitur...
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Homogeneous hydrogenation of barbituric acid derivatives with parahydrogen yields a substantial increase of the (1)H NMR signals of the reaction products. These physiologically relevant compounds were hydrogenated at both ambient and elevated temperatures and pressures using a standard cationic rhodium catalyst. The resulting nonthermal nuclear spin polarization (hyperpolarization) is limited b...
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Administration of 200 mg/kg of 5-fluorouracil (FUra) to mice bearing human colon carcinoma DLD-1 xenografts resulted in 100% mortality. Oral administration of 2000 mg/kg of 2',3',5'-tri-O-acetyluridine (TAU), a prodrug of uridine, in combination with 120 mg/kg of 5-(benzyloxybenzyl)barbituric acid acyclonucleoside (BBBA), the most potent known inhibitor of uridine phosphorylase (UrdPase, EC 2.4...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1969
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.17.810